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Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development.

Abstract
The discovery and development of paclitaxel, which covered a time span of some 30 years, has provided some important lessons for those involved in natural product drug discovery and development. These include the adoption of novel screens as they become available, the elucidation of mechanisms of action, and addressing the supply issue at an early stage of development. These issues, as applied to paclitaxel, are illustrated. The development of the NCI human cancer cell line screen, and its application to mechanistic studies through use of COMPARE analyses, are discussed, as is the production of the marine-derived anticancer agent, bryostatin 1, which provides another illustration of a successful approach to solving a supply issue. The history of the development of paclitaxel also illustrates the importance of multidisciplinary collaboration, and the various mechanisms used by the NCI Developmental Therapeutics Program for promoting such collaboration are presented.
AuthorsG M Cragg
JournalMedicinal research reviews (Med Res Rev) Vol. 18 Issue 5 Pg. 315-31 (Sep 1998) ISSN: 0198-6325 [Print] United States
PMID9735872 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents, Phytogenic
  • Paclitaxel
Topics
  • Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
  • Cooperative Behavior
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Humans
  • Paclitaxel (isolation & purification, pharmacology)
  • Tumor Cells, Cultured

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