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Synthesis and anticonvulsant properties of new N-piperazinylalkyl imides of succinic acid.

Abstract
A number of N-[(4-aryl)- or (4-methyl)-l-piperazinyl)alkyl]imides of 3-aryl or 3,3-pentamethylenesuccinic acid were synthesized and tested for anticonvulsant activity in the maximum electroshock seizure (MES) and pentylenetetrazole seizure threshold (scMet) tests. Structures of the novel compounds were confirmed by elemental and spectral analyses.
AuthorsJ Obniska, K Kulig, A Zejc
JournalActa poloniae pharmaceutica (Acta Pol Pharm) Vol. 55 Issue 3 Pg. 223-31 ( 1998) ISSN: 0001-6837 [Print] Poland
PMID9735703 (Publication Type: Journal Article)
Chemical References
  • Anticonvulsants
  • Piperazines
  • Succinates
Topics
  • Animals
  • Anticonvulsants (chemical synthesis, pharmacology)
  • Electroshock
  • Mice
  • Piperazines (chemical synthesis, pharmacology)
  • Seizures (prevention & control)
  • Structure-Activity Relationship
  • Succinates (chemical synthesis, pharmacology)

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