Abstract | BACKGROUND: OBJECTIVE: DESIGN: Case series. SETTING: University hospital. PATIENTS: INTERVENTION: MEASUREMENTS: Disease extent, disease activity, and blood eosinophil count in a treatment period ranging from 14 to 25 months. RESULTS:
Interferon-alpha therapy led to remission of disease and a substantial reduction of the prednisolone requirement in two patients who had attained incomplete remission with cyclophosphamide or methotrexate. The third patient's condition stabilized, and the fourth patient maintained remission. During interferon-alpha therapy, the blood eosinophil count in all patients decreased in a dose-dependent manner and paralleled the extent of clinical disease and disease activity. CONCLUSIONS:
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Authors | E Tatsis, A Schnabel, W L Gross |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 129
Issue 5
Pg. 370-4
(Sep 01 1998)
ISSN: 0003-4819 [Print] United States |
PMID | 9735064
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Glucocorticoids
- Immunosuppressive Agents
- Interferon-alpha
- Cyclophosphamide
- Prednisolone
- Methotrexate
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Topics |
- Adult
- Churg-Strauss Syndrome
(blood, drug therapy)
- Cyclophosphamide
(therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Eosinophils
(drug effects)
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Immunosuppressive Agents
(therapeutic use)
- Interferon-alpha
(administration & dosage, therapeutic use)
- Leukocyte Count
(drug effects)
- Male
- Methotrexate
(therapeutic use)
- Middle Aged
- Prednisolone
(therapeutic use)
- Remission Induction
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