Antidotal effect of grape juice (Vitis vinifera) on ochratoxin A caused hepatorenal carcinogenesis in mice (Mus musculus).

Abstract

Oral administration of ochratoxin A to young weanling mice (Mus musculus) caused several haematological changes and induced hepatoma and renal carcinoma. Concurrent administration of berry and leaf juice of the common grape (Vitis vinifera) to mice together with ochratoxin A significantly reduced the hepatic and renal damage caused by ingestion of this mycotoxin. None of the animals receiving berry/leaf juice of V. vinifera showed the formation of hepatorenal carcinoma whereas 25% of animals receiving only ochratoxin A developed well differentiated renal carcinoma and hepatic lesions.

• Authors: P Jeswal
• Journal: Cytobios (Cytobios) Vol. 93 Issue 373 Pg. 123-8 ( 1998) ISSN: 0011-4529 [Print] England
• PMID: 9734345 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antidotes
• Carcinogens
• Ochratoxins
• ochratoxin A
• Ascorbic Acid
• Thiamine

Topics

• Animals
• Antidotes (pharmacology)
• Ascorbic Acid
• Carcinogens
• Carcinoma, Hepatocellular (chemically induced, prevention & control)
• Carcinoma, Renal Cell (chemically induced, prevention & control)
• Kidney Neoplasms (chemically induced, prevention & control)
• Liver Neoplasms (chemically induced, prevention & control)
• Mice
• Ochratoxins
• Plant Leaves (chemistry)
• Rosales
• Thiamine