Cure of H. pylori infection using a 7-day triple therapy combining pantoprazole with two antibiotics.

Abstract

BACKGROUND:

Acid pump inhibitors combined with antimicrobials cure gastritis and peptic ulcer disease but a standard therapy has not yet been established. We therefore investigated a triple therapy with pantoprazole.

METHODS:

The aim of this open-label monocenter trial, involving 30 intention-to-treat patients with peptic ulcer disease or functional dyspepsia, was to assess the H. pylori cure rate after a 7-day triple therapy with pantoprazole (40 mg bid) plus metronidazole (500 mg bid) and amoxicillin (1 g bid). The H. pylori status was assessed by rapid urease test, histological examination and culture at the initial examination and by histological examination and culture at the study end 4 weeks after ending all therapy.

RESULTS:

At the end of the trial H. pylori was eradicated in 21 of 27 per protocol patients (78%; 95% CI 58-91%) and in 21 of 30 patients included in the trial (70%; 95% CI 51-85%). In 15 of 16 per protocol patients with metronidazole-sensitive strain (94%; 95% CI 70-100%) the infection was cured, but in contrast eradication was accomplished in only one of 3 patients with a metronidazole-resistant H. pylori strain. Post-treatment resistance to metronidazole was observed in 6 cases, although 4 of them had had H. pylori strains sensitive to metronidazole at the initial visit. The gastritis had clearly been improved, and the activity of gastritis had completely disappeared 4 weeks after treatment. Seven adverse events were observed in 7 patients, the intensity of which was moderate in 6 cases.

CONCLUSIONS:

This short-term triple therapy with pantoprazole, amoxicillin and metronidazole provides an effective regimen especially in patients with metronidazole-sensitive strain.

• Authors: R J Adamek, B Pfaffenbach, C Szymanski
• Journal: Helicobacter (Helicobacter) Vol. 3 Issue 3 Pg. 206-11 (Sep 1998) ISSN: 1083-4389 [Print] England
• PMID: 9731993 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Bacterial Agents
• Anti-Ulcer Agents
• Benzimidazoles
• Penicillins
• Sulfoxides
• Metronidazole
• Amoxicillin
• Pantoprazole
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Adolescent
• Adult
• Aged
• Amoxicillin (administration & dosage, adverse effects, therapeutic use)
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Anti-Ulcer Agents (administration & dosage, adverse effects, therapeutic use)
• Benzimidazoles (administration & dosage, adverse effects, therapeutic use)
• Drug Therapy, Combination
• Dyspepsia (drug therapy, microbiology)
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Metronidazole (administration & dosage, adverse effects, therapeutic use)
• Middle Aged
• Omeprazole (analogs & derivatives)
• Pantoprazole
• Patient Compliance
• Penicillins (administration & dosage, adverse effects, therapeutic use)
• Peptic Ulcer (drug therapy, microbiology)
• Sulfoxides (administration & dosage, adverse effects, therapeutic use)
• Treatment Outcome