Abstract | OBJECTIVE: METHODS: RESULTS: CONCLUSION: Hyperbaric transfection of antisense oligodeoxynucleotides proved highly efficient, effective at blockade of intracellular adhesion molecule-1, and demonstrated a sequence-specific reduction in chronic graft vascular disease. This highly targeted alteration of donor organ immunogenicity may have an important future role in clinical immunosuppressive strategies.
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Authors | R S Poston, M Ennen, J Pollard, E G Hoyt, M E Billingham, R C Robbins |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 116
Issue 3
Pg. 386-96
(Sep 1998)
ISSN: 0022-5223 [Print] United States |
PMID | 9731779
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Oligonucleotides, Antisense
- Intercellular Adhesion Molecule-1
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Topics |
- Animals
- Coronary Disease
(etiology, immunology, prevention & control)
- Genetic Therapy
(methods)
- Graft Rejection
(immunology, prevention & control)
- Heart Transplantation
(adverse effects)
- Immunosuppression Therapy
(methods)
- Intercellular Adhesion Molecule-1
(genetics, physiology)
- Male
- Myocardial Reperfusion Injury
(etiology, immunology, prevention & control)
- Oligonucleotides, Antisense
(therapeutic use)
- Postoperative Complications
(etiology, immunology, prevention & control)
- Pressure
- Rats
- Rats, Inbred ACI
- Rats, Inbred Strains
- Transfection
- Transplantation, Heterotopic
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