Synthesis and anticonvulsant properties of triazolo- and imidazopyridazinyl carboxamides and carboxylic acids.

Abstract

Analogues of 3-amino-7-(2,6-dichlorobenzyl)-6-methyltriazolo[4,3-b]pyridazine PC25 containing amide or carboxylic acid function were synthesized and tested for anticonvulsant activity. The compounds having the imidazole ring substituted with an amide group have been found to be generally more active against maximal electroshock-induced seizures in mice (15.2 < or = ED50 < or = 37.5 mg kg(-1) orally). Furthermore, maximum activity was generally associated with a 2,6-dichlorobenzyl substitution pattern. 3-Amido-7-(2,6-dichlorobenzyl)-6-methyltriazolo[4,3-b]pyridazine 4b was also protective in the pentylenetetrazole-induced seizures test (ED50 = 91.1 mg kg(-1) orally) and blocked strychnine-induced tonic extensor seizures (ED50 = 62.9 mg kg(-1) orally). Moreover, calculated electrostatic isopotential maps of the whole active compounds were quite similar and, consequently, could be associated to optimum anticonvulsant activity.

• Authors: S Moreau, P Coudert, C Rubat, D Vallee-Goyet, D Gardette, J C Gramain, J Couquelet
• Journal: Bioorganic & medicinal chemistry (Bioorg Med Chem) Vol. 6 Issue 7 Pg. 983-91 (Jul 1998) ISSN: 0968-0896 [Print] England
• PMID: 9730234 (Publication Type: Journal Article)

Chemical References

• Anticonvulsants
• Pyridazines

Topics

• Administration, Oral
• Animals
• Anticonvulsants (administration & dosage, chemical synthesis, chemistry, pharmacology)
• Electroshock
• Mice
• Models, Molecular
• Motor Activity (drug effects)
• Pyridazines (administration & dosage, chemical synthesis, chemistry, pharmacology)
• Seizures (chemically induced, prevention & control)
• Structure-Activity Relationship