Abstract | PURPOSE: METHODS: RESULTS: A cellular immune response against recoverin was found only in the patient with the condition resembling cancer-associated retinopathy. Elevated levels of antibody against recoverin were found in this patient and in one of the three patients with a retinal degeneration, but in none of the eight patients with uveitis. In contrast, moderate lymphocyte responses to retinal S-antigen were found in most of the patients studied, and this response did not distinguish among the patient groups. Levels of serum antibodies against retinal S-antigen were also similar in all patients tested. Serum from the patient with disease resembling cancer-associated retinopathy produced strong immunostaining of the rods, cones, outer plexiform layer, and some cone bipolar cells, but serum from the patients with uveitis or other retinal degenerations did not show specific reactivity with the retina. CONCLUSIONS: We propose that this immunologically and clinically distinctive condition be termed recoverin-associated retinopathy, and we suggest that a cellular immune response against recoverin may be a distinguishing feature of the disorder.
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Authors | S M Whitcup, B P Vistica, A H Milam, R B Nussenblatt, I Gery |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 126
Issue 2
Pg. 230-7
(Aug 1998)
ISSN: 0002-9394 [Print] United States |
PMID | 9727517
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antigens, Neoplasm
- Arrestin
- Autoantibodies
- Autoantigens
- Calcium-Binding Proteins
- Eye Proteins
- Immunoglobulins
- Lipoproteins
- Nerve Tissue Proteins
- RCVRN protein, human
- Recoverin
- Hippocalcin
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Topics |
- Adenolymphoma
(complications, surgery)
- Animals
- Antigens, Neoplasm
(immunology)
- Arrestin
(immunology)
- Autoantibodies
(analysis)
- Autoantigens
(immunology)
- Autoimmune Diseases
(etiology, immunology, pathology)
- Calcium-Binding Proteins
(immunology)
- Electroretinography
- Enzyme-Linked Immunosorbent Assay
- Eye Proteins
- Female
- Fluorescent Antibody Technique, Indirect
- Hippocalcin
- Humans
- Immunity, Cellular
- Immunoglobulins
(analysis)
- Lipoproteins
- Lymphocyte Activation
(immunology)
- Macaca
- Middle Aged
- Nerve Tissue Proteins
- Paraneoplastic Syndromes
(etiology, immunology, pathology)
- Parotid Neoplasms
(complications, surgery)
- Recoverin
- Retina
(immunology)
- Retinal Degeneration
(immunology)
- Retinal Diseases
(etiology, immunology, pathology)
- Uveitis
(immunology)
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