Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids.

Rabbit aorta contracting substance-releasing factor (RCS-RF) is found in perfusates from guinea pig lungs during anaphylaxis. It has been identified as a small peptide which releases arachidonic acid from lung tissue, thus generating prostaglandin endoperoxides and tbromboxanes and causing bronchocconstriction. Anti-inflammatory steroids block the release of arachidonate by RCS-RF. In this activity their relative potency is very similar to their relative anti-inflammatory potency, suggesting that the two actions may be related.
AuthorsF P Nijkamp, R J Flower, S Moncada, J R Vane
JournalNature (Nature) Vol. 263 Issue 5577 Pg. 479-82 (Oct 7 1976) ISSN: 0028-0836 [Print] ENGLAND
PMID972692 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Arachidonic Acids
  • Hydroxy Acids
  • Peptides
  • Prostaglandins
  • Pyrans
  • Animals
  • Anti-Inflammatory Agents (pharmacology)
  • Arachidonic Acids (metabolism)
  • Guinea Pigs
  • Hydroxy Acids (metabolism)
  • Lung (analysis, enzymology, metabolism)
  • Male
  • Peptides (isolation & purification)
  • Prostaglandins (metabolism)
  • Pyrans (metabolism)
  • Rabbits

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