Partial purification of rabbit aorta contracting substance-releasing factor and inhibition of its activity by anti-inflammatory steroids.

Abstract

Rabbit aorta contracting substance-releasing factor (RCS-RF) is found in perfusates from guinea pig lungs during anaphylaxis. It has been identified as a small peptide which releases arachidonic acid from lung tissue, thus generating prostaglandin endoperoxides and tbromboxanes and causing bronchocconstriction. Anti-inflammatory steroids block the release of arachidonate by RCS-RF. In this activity their relative potency is very similar to their relative anti-inflammatory potency, suggesting that the two actions may be related.

• Authors: F P Nijkamp, R J Flower, S Moncada, J R Vane
• Journal: Nature (Nature) Vol. 263 Issue 5577 Pg. 479-82 (Oct 07 1976) ISSN: 0028-0836 [Print] England
• PMID: 972692 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Arachidonic Acids
• Hydroxy Acids
• Intercellular Signaling Peptides and Proteins
• Peptides
• Prostaglandins
• Pyrans
• RCS-RF

Topics

• Animals
• Anti-Inflammatory Agents (pharmacology)
• Arachidonic Acids (metabolism)
• Guinea Pigs
• Hydroxy Acids (metabolism)
• Intercellular Signaling Peptides and Proteins
• Lung (analysis, enzymology, metabolism)
• Male
• Peptides (isolation & purification)
• Prostaglandins (metabolism)
• Pyrans (metabolism)
• Rabbits