Selenium-dependent and selenium-non-dependent glutathione peroxidase in patients with Balkan endemic nephropathy.

Abstract

We studied the activity of erythrocyte selenium (Se)-dependent, Se-non-dependent glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in uremic patients (UP) in clinically healthy members from families affected with Balkan nephropathy (HMF/BEN) and in healthy volunteers from endemic settlements (control group). The SOD activity was not significantly different in the groups studied and the Se-non-dependent GSH-Px activity in HMF/BEN and UP was not different from the control group. However, the activity of Se-dependent GSH-Px in UP was lower compared with the control group, whereas the mean value of the Se-dependent GSH-Px activity in HMF/BEN was not significantly different when compared with the other two investigated groups.

• Authors: G Grubor-Lajsic, V B Djordjević, A Jovanovic-Galović, N Lecić, V Djordjević, M Spasić
• Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer (J Environ Pathol Toxicol Oncol) Vol. 17 Issue 3-4 Pg. 321-4 ( 1998) ISSN: 0731-8898 [Print] United States
• PMID: 9726809 (Publication Type: Journal Article)

Chemical References

• Urea
• Creatinine
• Glutathione Peroxidase
• Superoxide Dismutase
• Selenium

Topics

• Balkan Nephropathy (blood, enzymology, physiopathology)
• Creatinine (blood)
• Erythrocytes (enzymology)
• Glutathione Peroxidase (blood)
• Humans
• Kidney (physiopathology)
• Selenium (blood)
• Superoxide Dismutase (blood)
• Urea (blood)