Abstract | OBJECTIVES: DESIGN: SETTING: The dermatologic clinics of the University of Minnesota, Minneapolis; the Mayo Clinic, Rochester, Minn; and the University of California-Davis Medical Center, Sacramento. PATIENTS: MAIN OUTCOME MEASURES: Clinical, laboratory, and histopathologic findings. RESULTS: Extensive skin blistering accompanied by the Nikolsky sign and suprabasilar acantholysis was induced in the Dsg3null mice that received pemphigus, but not normal human IgGs. In the radioimmunoprecipitation assays for reactivity with cholinergic receptors, the mean radioactivity precipitated by pemphigus serum samples significantly exceeded both normal- and disease-control levels (P = .001-.02). The mean individual levels of radioactivity precipitated by 34 pemphigus vulgaris and pemphigus foliaceus serum samples (85%) exceeded control values by a mean of approximately 2.6 times. CONCLUSIONS:
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Authors | T N Vu, T X Lee, A Ndoye, L D Shultz, M R Pittelkow, M V Dahl, P J Lynch, S A Grando |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 134
Issue 8
Pg. 971-80
(Aug 1998)
ISSN: 0003-987X [Print] United States |
PMID | 9722727
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Autoantibodies
- Cell Adhesion Molecules
- Cytoskeletal Proteins
- Desmoplakins
- Immunoglobulin G
- Receptors, Cholinergic
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Topics |
- Acantholysis
(immunology)
- Adult
- Aged
- Aged, 80 and over
- Animals
- Autoantibodies
(biosynthesis)
- Case-Control Studies
- Cell Adhesion
(immunology)
- Cell Adhesion Molecules
(immunology)
- Cytoskeletal Proteins
(immunology)
- Dermatitis, Contact
(immunology)
- Desmoplakins
- Desmosomes
(immunology)
- Erythema Nodosum
(immunology)
- Female
- Genetic Engineering
- Humans
- Immunoglobulin G
(immunology)
- Keratinocytes
(immunology)
- Lupus Erythematosus, Systemic
(immunology)
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Middle Aged
- Pemphigoid, Bullous
(immunology)
- Pemphigus
(classification, immunology)
- Receptors, Cholinergic
(immunology)
- Skin Diseases, Vesiculobullous
(immunology)
- Skin Ulcer
(immunology)
- Urticaria
(immunology)
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