Reactivity to recombinant house-dust-mite allergens in asthma and rhinitis in a tropical environment.

Abstract

BACKGROUND:

House-dust mites contain components that are allergenic in mite-sensitive patients, and a number of these have been produced in recombinant form.

METHODS:

In the present study, we evaluated by skin prick testing the positivity to native Der p 2 and recombinant Der p 2, Der p 5, and Der p 7 allergens of Dermatophagoides pteronyssinus in patients with rhinitis, asthma, or a combination of these diseases, who were positive to whole-mite extract.

RESULTS:

In all patients, the positivity to both native and recombinant Der p 2 was high. In patients with either rhinitis or asthma, the reactivity to Der p 5 and 7 was significantly lower than to Der p 2. However, in patients with combined disease, the positivity to the minor allergens was almost as high as that to Der p 2.

CONCLUSIONS:

These results raise the question of whether patients with combined allergic rhinitis and asthma, when compared to those with either of these diseases alone, are predisposed to react to a wider range of mite allergens, or, inversely, whether patients who respond to the minor allergens are more susceptible to suffering the combined disease.

• Authors: N R Lynch, F A Puccio, M C Di Prisco, R I Lopez, L A Hazell, W A Smith, W R Thomas
• Journal: Allergy (Allergy) Vol. 53 Issue 8 Pg. 808-11 (Aug 1998) ISSN: 0105-4538 [Print] Denmark
• PMID: 9722232 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Antigens, Dermatophagoides
• Dust
• Glycoproteins
• Recombinant Fusion Proteins
• Glutathione Transferase

Topics

• Administration, Inhalation
• Adolescent
• Adult
• Allergens (immunology)
• Animals
• Antigens, Dermatophagoides
• Asthma (immunology)
• Child
• Dust (adverse effects)
• Escherichia coli (genetics)
• Female
• Glutathione Transferase (genetics)
• Glycoproteins (immunology)
• Humans
• Male
• Middle Aged
• Mites (immunology)
• Recombinant Fusion Proteins (immunology)
• Rhinitis, Allergic, Perennial (immunology)
• Skin Tests
• Tropical Climate
• Venezuela