CD5 negative B-cell chronic lymphocytic leukemia: clinical and biological features of 42 cases.
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| Abstract |
Chronic lymphocytic leukemia cell (CLL) usually (95%) express B-phenotype and the CD5 antigen which is usually present on the surface of normal T cells. However, among B CLL, 7 to 20% do not express CD5. The significance of the lack of CD5 expression remains unclear. We reviewed 42 consecutive CD5- B CLL seen in three French medical centers from 1985 to 1991 and compared them with 79 CD5+ B CLL. Immunophenotype studies were performed using indirect immunofluorescence under light microscopy as well as flow cytometry after 1988. B CLL was considered to be CD5 negative when less than 5% of mononuclear cells expressed CD5 after subtraction of the number of T-cells. Cases with CD5- B CLL had isolated splenomegaly more frequently (p = 2.10(-7)). They frequently expressed a higher level of surface immunoglobulin (S-Ig) or the switch mu/delta phenotype (p = 4.7 10(-2)). The median survival time was not reached but no significant difference between CD5 negative and positive B CLL was observed at the time of our data analysis (p = 0.97). Clinical presentation of CD5- B CLL seems to be different from other forms of B CLL. Although, no conclusion can be reached in terms of prognosis, CLL with low expression of CD5 should be regarded as a subtype of CLL with a different clinical presentation than CD5+ CLL.
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| Authors | G Cartron, C Linassier, J L Bremond, B Desablens, M T Georget, B Fimbel, F Luthier, J L Dutel, J P Lamagnere, P Colombat |
| Journal | Leukemia & lymphoma (Leuk Lymphoma) Vol. 31 Issue 1-2 Pg. 209-16 (Sep 1998) ISSN: 1042-8194 [Print] United States |
| PMID | 9720730 (Publication Type: Journal Article) |
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