Hyporeninemic hypoaldosteronism after chronic sodium bicarbonate abuse.

Abstract

We describe a 52-year-old man who, following the discontinuation of massive intake of sodium bicarbonate, in the absence of renal insufficiency, developed progressive hyperkalemia and hyponatremia in association with hyporeninemic hypoaldosteronism. The mechanism of this syndrome is not known, but may involve suppression of the renin-angiotensin-aldosterone axis by chronic volume expansion.

• Authors: J R Oster, G O Perez, M S Rosen
• Journal: Archives of internal medicine (Arch Intern Med) Vol. 136 Issue 10 Pg. 1179-80 (Oct 1976) ISSN: 0003-9926 [Print] United States
• PMID: 971018 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bicarbonates
• Aldosterone
• Sodium
• Renin
• Potassium

Topics

• Aldosterone (blood, deficiency)
• Bicarbonates (adverse effects)
• Dose-Response Relationship, Drug
• Dyspnea (chemically induced)
• Humans
• Hyperkalemia (blood)
• Hyponatremia (blood)
• Kidney Function Tests
• Male
• Middle Aged
• Potassium (blood)
• Renin (blood, deficiency)
• Sodium (blood)
• Substance-Related Disorders