Abstract | OBJECTIVES: The purpose of this study was to assess the effects of enalapril and nitrendipine on the cardiac sympathetic nervous system. BACKGROUND: METHODS: 123I-metaiodobenzylguanidine ( MIBG) cardiac imaging was performed before and 3 months after drug administration in 46 patients with mild essential hypertension. Twenty-two patients were treated with 5 to 10 mg of enalapril once a day, and the other 24 with 5 to 10 mg of nitrendipine once a day. For comparison, 20 normotensive subjects were also studied. RESULTS: There were no significant differences between the basal characteristics in the 2 hypertensive groups. In both hypertensive groups, both systolic and diastolic blood pressures were significantly reduced to similar levels after the 3-month drug treatment. Before the drug treatment, the 2 hypertensive groups had a significantly higher washout rate and lower MIBG uptake than the normotensive subjects. The heart-to-mediastinum ratio significantly increased (p < 0.0001), with decreased (p < 0.002) washout rate after drug treatment in the enalapril group, but with no significant changes in the nitrendipine group. CONCLUSION:
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Authors | K Sakata, M Shirotani, H Yoshida, C Kurata |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 32
Issue 2
Pg. 438-43
(Aug 1998)
ISSN: 0735-1097 [Print] United States |
PMID | 9708473
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Antihypertensive Agents
- Calcium Channel Blockers
- Radiopharmaceuticals
- 3-Iodobenzylguanidine
- Enalapril
- Nitrendipine
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Topics |
- 3-Iodobenzylguanidine
- Adult
- Aged
- Analysis of Variance
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Antihypertensive Agents
(administration & dosage, therapeutic use)
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(administration & dosage, therapeutic use)
- Enalapril
(administration & dosage, therapeutic use)
- Follow-Up Studies
- Heart Conduction System
(diagnostic imaging, drug effects)
- Humans
- Hypertension
(diagnostic imaging, drug therapy, physiopathology)
- Male
- Mediastinum
(diagnostic imaging)
- Middle Aged
- Nitrendipine
(administration & dosage, therapeutic use)
- Prognosis
- Radionuclide Imaging
- Radiopharmaceuticals
- Sympathetic Nervous System
(diagnostic imaging, drug effects)
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