Chronic ulcerative colitis, skin necrosis, and cryofibrinogenemia.

Abstract

Necrotizing skin lesions developed in a man with chronic ulcerative colitis. No evidence of intrinsic disease of medium or small-sized vessels was found. A circulating cryofibrinogen was thought to be responsible for in situ thrombosis leading to skin infarctions. Sodium warfarin in a daily dose of 2.5 to 5 mg appears to have thwarted progression of developing lesions and the occurrence of new ones.

• Authors: G V Ball, L N Goldman
• Journal: Annals of internal medicine (Ann Intern Med) Vol. 85 Issue 4 Pg. 464-6 (Oct 1976) ISSN: 0003-4819 [Print] United States
• PMID: 970774 (Publication Type: Case Reports, Journal Article)

Chemical References

• Warfarin
• Fibrinogen

Topics

• Blood Protein Disorders (complications)
• Chronic Disease
• Cold Temperature
• Colitis, Ulcerative (complications)
• Fibrinogen
• Humans
• Male
• Middle Aged
• Necrosis
• Skin Diseases (drug therapy, etiology, pathology)
• Warfarin (therapeutic use)