Carcinogenesis by benzenediazonium sulfate in mice.

Abstract

Benzenediazonium sulfate (BD) was given to Swiss mice by 26 subcutaneous injections of 10 micrograms/g body weight at weekly intervals. The treatment gave rise to tumors of the subcutis. The tumor incidences in the treated groups were 42% in females and 26% in males. The corresponding tumor incidences in the untreated controls were 0% in females and 2% in males. Histopathologically, the neoplasms were classified as fibrosarcomas, rhabdomyosarcomas, and osteosarcomas of the subcutaneous tissue. BD is formed during the cytochrome P-450 catalyzed metabolism of the carcinogenic 1-(phenylazo)-2-hydroxynaphthalene (Sudan I, Solvent Yellow 14), which was used as a coloring agent for food and other materials in several countries. Further, BD is a metabolic breakdown product of different classes of nitrogen-nitrogen bond- containing chemicals. BD is the fourth benzenediazonium salt found to be carcinogenic in this laboratory.

• Authors: B Toth, K Patil, J Erickson, P Gannett
• Journal: In vivo (Athens, Greece) (In Vivo) 1998 Jul-Aug Vol. 12 Issue 4 Pg. 379-82 ISSN: 0258-851X [Print] Greece
• PMID: 9706488 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Diazonium Compounds
• benzenediazonium

Topics

• Animals
• Carcinogenicity Tests
• Carcinogens (chemistry, pharmacology)
• Diazonium Compounds (chemistry, pharmacology)
• Female
• Fibrosarcoma (chemically induced)
• Male
• Mice
• Molecular Structure
• Osteosarcoma (chemically induced)
• Rhabdomyosarcoma (chemically induced)