[A basic study of photodynamic therapy of experimental hepatoma with ME 2906].

Abstract

We have studied effects of photodynamic diagnosis (PDD) and photodynamic therapy (PDT) in hepatoma as confirmed by the existence of hepatoma when using a new photosensitizer mono-L-aspartyl chlorin e6. Japanese white rabbits were selected to perform abdominal incision under intravenous anesthesia and transplant VX2 tumor cells into the liver left lobe for the hepatoma model. Hepatoma of 1 cm in diameter (at one week after transplantation) was used experimentally to radiate a semiconductor laser (664 nm, 200 J/cm2) for treatment.

• Authors: J Nakamura, H Kajiwara, M Nakamura, M Watanabe, K Naganuma, H Tanaka, S Usui, Y Sumiyama, K Saito, K Aizawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 25 Issue 9 Pg. 1454-6 (Jul 1998) ISSN: 0385-0684 [Print] Japan
• PMID: 9703852 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Photosensitizing Agents
• Porphyrins
• Talaporfin

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• Liver Neoplasms, Experimental (drug therapy, pathology)
• Male
• Photochemotherapy
• Photosensitizing Agents (therapeutic use)
• Porphyrins (therapeutic use)
• Rabbits