[Effect of the proteolytic substance morikrase on the status of scar tissue under in vitro conditions].

Abstract

Proteolytical preparation moricrasa was isolated from hepatopancreas of Paralithodes camtshatic. Moricrasa and its fractions were used for lysis of cicatricial tissue under in vitro conditions. It was found that moricrasa in concentrations 0.5 mg/ml and 2 mg/ml lysed the cicatrix during 72 and 14-16 hours, respectively. The fraction consisted of collagenolytic proteinase PC and trypsin revealed maximal activity of fraction of moricrasa was absent.

• Authors: L V Liutova, M A Karabasova, G V Andreenko, G N Rudenskaia, V A Isaev, A B Brusov
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1998 May-Jun Vol. 44 Issue 3 Pg. 292-5 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie proteoliticheskogo preparata morikrazy na sostoianie rubtsovoĭ tkani v usloviiakh in vitro.
• PMID: 9703631 (Publication Type: English Abstract, Journal Article)

Chemical References

• Fibrinolytic Agents
• Multienzyme Complexes
• Collagen
• Endopeptidases
• morikrase

Topics

• Animals
• Brachyura (chemistry)
• Cicatrix (metabolism)
• Collagen (metabolism)
• Endopeptidases (isolation & purification, pharmacology)
• Fibrinolytic Agents (pharmacology)
• Hydrolysis
• Multienzyme Complexes (isolation & purification, pharmacology)