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Combination assay of CSF tau, A beta 1-40 and A beta 1-42(43) as a biochemical marker of Alzheimer's disease.

Abstract
Cerebrospinal fluid samples from a total of 157 subjects consisting of 55 patients with sporadic Alzheimer's disease (AD), 34 normal controls, 23 patients with non-AD dementia, and 45 with other neurological diseases were examined by ELISA of tau, A beta 1-40, and A beta 1-42(43). The AD group had a significantly higher level of tau than the normal control group (P < 0.001), and the diagnostic sensitivity was 31% and specificity was 94%. CSF A beta 1-40 levels did not show any significant differences. Although the level of A beta 1-42(43) was decreased significantly in the AD group compared to the control group (P < 0.005), the overlap of A beta 1-42(43) levels among all groups meant that none of the AD samples exceeded the cut-off value, the mean 2SD of normal control subjects. Reduction of A beta 1-42(43) levels in AD resulted in a significant increase in the ratio of A beta 1-40 to A beta 1-42(43) (A beta ratio) as an improved marker. The diagnostic sensitivity and specificity of A beta ratio were 51% and 82% respectively. The three indexes, using the tau level and A beta ratio (tau or A beta ratio, deviation score and tau x A beta ratio), showed better sensitivity (58%, 67%, 69%) and specificity (82%, 86%, 88%) than previously reported methods. Combination assay for CSF tau, A beta 1-40 and A beta 1-42(43) in CSF is a biological marker of AD and may be useful to biochemically monitor subjects under treatment.
AuthorsM Shoji, E Matsubara, M Kanai, M Watanabe, T Nakamura, Y Tomidokoro, M Shizuka, K Wakabayashi, Y Igeta, Y Ikeda, K Mizushima, M Amari, K Ishiguro, T Kawarabayashi, Y Harigaya, K Okamoto, S Hirai
JournalJournal of the neurological sciences (J Neurol Sci) Vol. 158 Issue 2 Pg. 134-40 (Jun 30 1998) ISSN: 0022-510X [Print] Netherlands
PMID9702683 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid beta-Peptides
  • Biomarkers
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • amyloid beta-protein (1-42)
  • amyloid beta-protein (1-43)
  • tau Proteins
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease (cerebrospinal fluid)
  • Amyloid beta-Peptides (cerebrospinal fluid)
  • Biomarkers
  • Dementia (cerebrospinal fluid)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases (cerebrospinal fluid)
  • Peptide Fragments (cerebrospinal fluid)
  • Reference Values
  • tau Proteins (cerebrospinal fluid)

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