Endotoxin removal column containing polymyxin B immobilized fiber is useful for the treatment of the patient with Vibrio vulnificus septicemia.

A case of primary septicemia due to Vibrio vulnificus infection is reported. The patient was successfully treated with appropriate antibiotic therapy, drainage, and debridement of the necrotic tissues and direct hemoperfusion (DHP) using polymyxin B immobilized fiber (PMX-F). The effectiveness of DHP using PMX-F, which removes endotoxin in the circulating blood for the treatment of septic shock and multiple organ dysfunction occurring due to this fulminant infectious disease, is discussed.
AuthorsT Sato, N Tadakuma, N Ikezaki, A Hashiguchi, K Masuda
JournalArtificial organs (Artif Organs) Vol. 22 Issue 8 Pg. 705-7 (Aug 1998) ISSN: 0160-564X [Print] UNITED STATES
PMID9702324 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Polymyxin B
  • Anti-Bacterial Agents (administration & dosage)
  • Endotoxemia (therapy)
  • Hemoperfusion (instrumentation)
  • Humans
  • Male
  • Middle Aged
  • Polymyxin B (administration & dosage)
  • Sepsis (therapy)
  • Vibrio Infections (therapy)

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