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A comparison of 10 and 14 days of lansoprazole triple therapy for eradication of Helicobacter pylori.

AbstractBACKGROUND:
Data from large, multicenter, US studies determining the efficacy of triple therapy for the eradication of Helicobacter pylori are lacking, especially for a treatment duration of less than 14 days.
METHODS:
Patients with H pylori infection and active duodenal ulcer disease or a history of duodenal ulcer disease within the past year were randomized to receive 30 mg of lansoprazole, 1 g of amoxicillin, and 500 mg of clarithromycin twice daily for 10 or 14 days. The primary efficacy end point was the eradication of H pylori as confirmed by negative histological and culture results at 4 to 6 weeks after the completion of treatment.
RESULTS:
Of 284 patients enrolled in the study from 46 US sites, 236 met the entry criteria. At 4 to 6 weeks after the end of therapy, H pylori was eradicated in 85% (96/ 113) of the patients receiving 14-day triple therapy and in 84% (103/123) of those receiving 10-day triple therapy by per-protocol analysis (95% confidence interval for treatment group differences, -10.5 to 8.1; P>.05). There was also no significant difference between the 14- and 10-day treatment groups when analyzed by an intent-to-treat analysis of H pylori eradication. A similar proportion of patients in each treatment group reported an adverse event related to therapy (34% [46/136] vs 38% [56/148], respectively).
CONCLUSIONS:
In patients with an active or a recent history of duodenal ulcer, lansoprazole-based triple therapy for 10 or 14 days is highly effective in the eradication of H pylori. The duration of therapy may be reduced from 14 to 10 days without a significant effect on regimen efficacy.
AuthorsM B Fennerty, T O Kovacs, R Krause, M Haber, A Weissfeld, N Siepman, P Rose
JournalArchives of internal medicine (Arch Intern Med) 1998 Aug 10-24 Vol. 158 Issue 15 Pg. 1651-6 ISSN: 0003-9926 [Print] UNITED STATES
PMID9701099 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Proton Pump Inhibitors
  • Lansoprazole
  • Amoxicillin
  • Clarithromycin
  • Omeprazole
Topics
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Amoxicillin (administration & dosage, therapeutic use)
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Anti-Ulcer Agents (administration & dosage, therapeutic use)
  • Clarithromycin (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Duodenal Ulcer (drug therapy, microbiology)
  • Female
  • Helicobacter Infections (drug therapy)
  • Helicobacter pylori
  • Humans
  • Lansoprazole
  • Male
  • Middle Aged
  • Omeprazole (administration & dosage, analogs & derivatives, therapeutic use)
  • Proton Pump Inhibitors
  • Time Factors

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