A comparison of 10 and 14 days of lansoprazole triple therapy for eradication of Helicobacter pylori.

Data from large, multicenter, US studies determining the efficacy of triple therapy for the eradication of Helicobacter pylori are lacking, especially for a treatment duration of less than 14 days.
Patients with H pylori infection and active duodenal ulcer disease or a history of duodenal ulcer disease within the past year were randomized to receive 30 mg of lansoprazole, 1 g of amoxicillin, and 500 mg of clarithromycin twice daily for 10 or 14 days. The primary efficacy end point was the eradication of H pylori as confirmed by negative histological and culture results at 4 to 6 weeks after the completion of treatment.
Of 284 patients enrolled in the study from 46 US sites, 236 met the entry criteria. At 4 to 6 weeks after the end of therapy, H pylori was eradicated in 85% (96/ 113) of the patients receiving 14-day triple therapy and in 84% (103/123) of those receiving 10-day triple therapy by per-protocol analysis (95% confidence interval for treatment group differences, -10.5 to 8.1; P>.05). There was also no significant difference between the 14- and 10-day treatment groups when analyzed by an intent-to-treat analysis of H pylori eradication. A similar proportion of patients in each treatment group reported an adverse event related to therapy (34% [46/136] vs 38% [56/148], respectively).
In patients with an active or a recent history of duodenal ulcer, lansoprazole-based triple therapy for 10 or 14 days is highly effective in the eradication of H pylori. The duration of therapy may be reduced from 14 to 10 days without a significant effect on regimen efficacy.
AuthorsM B Fennerty, T O Kovacs, R Krause, M Haber, A Weissfeld, N Siepman, P Rose
JournalArchives of internal medicine (Arch Intern Med) 1998 Aug 10-24 Vol. 158 Issue 15 Pg. 1651-6 ISSN: 0003-9926 [Print] UNITED STATES
PMID9701099 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Anti-Bacterial Agents
  • Anti-Ulcer Agents
  • Proton Pump Inhibitors
  • Lansoprazole
  • Amoxicillin
  • Clarithromycin
  • Omeprazole
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Amoxicillin (administration & dosage, therapeutic use)
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Anti-Ulcer Agents (administration & dosage, therapeutic use)
  • Clarithromycin (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Duodenal Ulcer (drug therapy, microbiology)
  • Female
  • Helicobacter Infections (drug therapy)
  • Helicobacter pylori
  • Humans
  • Lansoprazole
  • Male
  • Middle Aged
  • Omeprazole (administration & dosage, analogs & derivatives, therapeutic use)
  • Proton Pump Inhibitors
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: