Abstract |
Premature female mice were injected daily with 1.5 mg/kg body weight of triamcinolone diacetate for 10 and 21 consecutive days. Electron-microscopic study of hepatocytes indicated the formation of 'giant' mitochondria concomitant with a marked increase in the number and size of lipid droplets. Hypertrophied mitochondria and enlarged lipid droplets were found to be in a close topographical association. The mechanism of mitochondrial enlargement is discussed as well as the latters' role in the hepatocytes' lipid metabolism.
|
Authors | R Ludatscher, M Silbermann |
Journal | Acta anatomica
(Acta Anat (Basel))
Vol. 96
Issue 2
Pg. 176-87
( 1976)
ISSN: 0001-5180 [Print] Switzerland |
PMID | 970101
(Publication Type: Journal Article)
|
Chemical References |
|
Topics |
- Animals
- Cytoplasm
(metabolism, ultrastructure)
- Female
- Lipid Metabolism
- Liver
(drug effects, ultrastructure)
- Mice
- Mitochondria, Liver
(drug effects, ultrastructure)
- Triamcinolone
(pharmacology)
|