Abstract |
It was found in white rats that hyperthyreosis (0.5% thyreoidin in dry food), respectively 2,4-dinitrophenol (30 mg/kg body weight/day i. p.), deficiency of the vitamins K and E or complete fasting increase the content of creatine in muscle, plasma and urine, but reduce the concentration of creatinine. Simultaneously the elevated creatine level of blood causes a repression of transamidinase in kidneys and pancreas. The common mode of action of the mentioned agents is seen in a decoupling of the oxidative phosphorylation, and in an insufficient availability of ATP, respectively.
|
Authors | J Methfessel, I Rodina |
Journal | Acta biologica et medica Germanica
(Acta Biol Med Ger)
Vol. 35
Issue 3-4
Pg. 317-23
( 1976)
ISSN: 0001-5318 [Print] Germany |
Vernacular Title | Einfluss entkoppelnder Agentien auf die Transamidinase-Kapazität von Nieren und Pankreas |
PMID | 970042
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Dinitrophenols
- Uncoupling Agents
- Adenosine Triphosphate
- Creatinine
- Amidinotransferases
- Creatine
|
Topics |
- Adenosine Triphosphate
(metabolism)
- Amidinotransferases
(metabolism)
- Animals
- Creatine
(metabolism)
- Creatinine
(metabolism)
- Dinitrophenols
(pharmacology)
- Fasting
- Hyperthyroidism
(enzymology)
- Kidney
(drug effects, enzymology)
- Oxidative Phosphorylation
(drug effects)
- Pancreas
(drug effects, enzymology)
- Rats
- Uncoupling Agents
(pharmacology)
- Vitamin E Deficiency
(enzymology)
- Vitamin K Deficiency
(enzymology)
|