Identification of nitric oxide synthase 2 as an innate resistance locus against ectromelia virus infection.

Abstract

To assess whether nitric oxide synthase 2 (NOS2) fulfills the criteria of an innate resistance locus against an acute viral infection, we inoculated genetically deficient NOS2-/- mice with virulent ectromelia virus (EV), the causative agent of mousepox. NOS2-/- mice proved highly susceptible to EV yet showed no diminution in other well-characterized anti-EV immune responses, i.e. , gamma interferon secretion and NK cell and EV-specific cytotoxic T lymphocyte activities. Thus, the NOS2 locus can be considered a critical monogenic determinant of EV resistance that contributes to host survival.

• Authors: G Karupiah, J H Chen, C F Nathan, S Mahalingam, J D MacMicking
• Journal: Journal of virology (J Virol) Vol. 72 Issue 9 Pg. 7703-6 (Sep 1998) ISSN: 0022-538X [Print] United States
• PMID: 9696880 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Nitric Oxide Synthase
• Nitric Oxide Synthase Type II
• Nos2 protein, mouse

Topics

• Animals
• Cell Line
• Chlorocebus aethiops
• Ectromelia virus (immunology, physiology)
• Female
• Gene Deletion
• Immunity, Innate
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Nitric Oxide Synthase (genetics, physiology)
• Nitric Oxide Synthase Type II