Prolonged disease-free survival in relapsed/refractory low-grade lymphoma treated with fludarabine: a report of four cases.

Abstract

We report four patients with relapsed or refractory follicular (three) and lymphoplasmacytic (one) lymphoma who achieved complete remission (CR) with fludarabine (FDR) lasting from 3.2 to 6 years. One had stage III and three stage IV and were resistant to chlorambucil and/or anthracycline. FDR was well tolerated, the only complication being herpes zoster infection in three patients, which was controlled with aciclovir. One patient developed a gastric MALT lymphoma from a different clone than the follicular lymphoma. In conclusion, some patients with refractory low-grade lymphoma achieve long-term CR with FDR: therefore this agent may be considered as alternative to stem-cell transplantation.

• Authors: A J Sternberg, E Matutes, S Killick, A C Wotherspoon, D Catovsky
• Journal: British journal of haematology (Br J Haematol) Vol. 102 Issue 2 Pg. 532-4 (Jul 1998) ISSN: 0007-1048 [Print] England
• PMID: 9695970 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anthracyclines
• Antineoplastic Agents
• Antineoplastic Agents, Alkylating
• Chlorambucil
• Vincristine
• Cyclophosphamide
• Vidarabine
• fludarabine
• Prednisone

Topics

• Adult
• Anthracyclines (therapeutic use)
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Agents, Alkylating (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chlorambucil (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Drug Resistance, Neoplasm
• Female
• Humans
• Lymphoma, Follicular (drug therapy)
• Lymphoma, Non-Hodgkin (drug therapy)
• Male
• Middle Aged
• Prednisone (therapeutic use)
• Vidarabine (analogs & derivatives, therapeutic use)
• Vincristine (therapeutic use)