Use of an oral antiseptic bioadhesive tablet in dogs.

Abstract

V3703 (Stomadhex) is a tablet with bioadhesive properties enabling it to remain in place for several hours after it has been placed on the oral mucosa. It continuously releases chlorhexidine and niacinamide. In a study conducted in 15 dogs, the tablets were well tolerated by the animals. The product significantly reduced (p < 0.05): dental plaque; quantitative periodontopathogen and total anaerobic bacterial counts; spirochetes; and halitosis when used daily over a 14 day period. Gingivitis was also reduced, though not significantly (p = 0.07). Stomadhex treatment can provide a carry-over effect following dental scaling by reducing oral microflora and retarding the reappearance of dental plaque.

• Authors: P Gruet, C Gaillard, B Boisramé, D Duffaut, A M Grimoud, G Camy
• Journal: Journal of veterinary dentistry (J Vet Dent) Vol. 12 Issue 3 Pg. 87-91 (Sep 1995) ISSN: 0898-7564 [Print] United States
• PMID: 9693631 (Publication Type: Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Drug Combinations
• Tablets
• Niacinamide
• Chlorhexidine

Topics

• Administration, Topical
• Analysis of Variance
• Animals
• Anti-Infective Agents, Local (administration & dosage)
• Bacteria, Anaerobic (drug effects)
• Chlorhexidine (administration & dosage)
• Colony Count, Microbial
• Dental Plaque (drug therapy, microbiology, veterinary)
• Dog Diseases (drug therapy, microbiology)
• Dogs
• Drug Combinations
• Gingivitis (drug therapy, veterinary)
• Halitosis (drug therapy, veterinary)
• Linear Models
• Mouth Mucosa
• Niacinamide (administration & dosage)
• Spirochaetales (drug effects)
• Tablets