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A comparison of fluvastatin 40 mg every other day versus 20 mg every day in patients with hypercholesterolemia.

AbstractSTUDY OBJECTIVE:
To assess the efficacy of fluvastatin administered every other day versus an equivalent dose given daily in patients with hypercholesterolemia.
DESIGN:
Randomized, nonblinded, crossover study.
SETTING:
Veterans Affairs Medical Center.
PATIENTS:
Twenty-three patients with low-density lipoprotein (LDL) levels above 160 mg/dl despite diet therapy
INTERVENTION:
Patients received fluvastatin 40 mg every other day or 20 mg/day, all doses taken at bedtime. Each treatment arm was 6 weeks in duration.
MEASUREMENTS AND MAIN RESULTS:
A lipid profile was determined at baseline and after each regimen. Both regimens significantly lowered total cholesterol and LDL versus baseline. The LDL levels were lowered by 24% and 21% by fluvastatin 20 mg/day and 40 mg every other day, respectively. There was no statistically significant difference in lipid components between regimens.
CONCLUSION:
Fluvastatin 40 mg every other day is effective in lowering total cholesterol and LDL in patients with hypercholesterolemia.
AuthorsJ P Rindone, D Hiller, G Arriola
JournalPharmacotherapy (Pharmacotherapy) 1998 Jul-Aug Vol. 18 Issue 4 Pg. 836-9 ISSN: 0277-0008 [Print] UNITED STATES
PMID9692657 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anticholesteremic Agents
  • Fatty Acids, Monounsaturated
  • Indoles
  • Lipoproteins, LDL
  • fluvastatin
  • Cholesterol
Topics
  • Aged
  • Anticholesteremic Agents (administration & dosage, adverse effects, therapeutic use)
  • Cholesterol (blood)
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Fatty Acids, Monounsaturated (administration & dosage, adverse effects, therapeutic use)
  • Female
  • Gastrointestinal Diseases (chemically induced)
  • Humans
  • Hypercholesterolemia (drug therapy)
  • Indoles (administration & dosage, adverse effects, therapeutic use)
  • Lipoproteins, LDL (blood, drug effects)
  • Liver (drug effects, physiopathology)
  • Liver Function Tests
  • Male
  • Middle Aged
  • Treatment Outcome
  • Urinary Retention (chemically induced)

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