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Reduced expression of calponin h1 in leiomyosarcoma of the uterus.

Abstract
To determine the genetic differences between various smooth muscle tumors of the uterus, the expression of calponin h1 (cytoskeletal protein) was examined in normal myometrium and in smooth muscle tumors of the uterus (leiomyosarcoma, smooth muscle tumors of uncertain malignant potential, cellular leiomyoma, bizarre leiomyoma, and ordinary leiomyoma) using immunohistochemistry and Western blotting. Analysis of calponin h1 transcripts using the reverse-transcription-PCR was also performed. Immunohistochemically, calponin h1 was expressed in normal myometrium and in all leiomyomas; however, its expression was markedly weaker in leiomyosarcoma. The results of both Western blotting and the analysis of calponin h1 transcripts were compatible with the immunohistochemical results. It is suggested that reduced expression of calponin h1 is associated with leiomyosarcoma of the uterus, and that calponin h1 expression may serve as a valuable molecular maker in the differential diagnosis of smooth muscle tumors of the uterus.
AuthorsA Horiuchi, T Nikaido, K Ito, Y Zhai, A Orii, S Taniguchi, T Toki, S Fujii
JournalLaboratory investigation; a journal of technical methods and pathology (Lab Invest) Vol. 78 Issue 7 Pg. 839-46 (Jul 1998) ISSN: 0023-6837 [Print] United States
PMID9690561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Calcium-Binding Proteins
  • Microfilament Proteins
  • calponin
Topics
  • Adult
  • Aged
  • Calcium-Binding Proteins (analysis, biosynthesis)
  • Cells, Cultured
  • Female
  • Follow-Up Studies
  • Humans
  • Hysterectomy
  • Immunohistochemistry
  • Leiomyoma (metabolism, pathology, surgery)
  • Leiomyosarcoma (metabolism, pathology, surgery)
  • Microfilament Proteins (biosynthesis)
  • Middle Aged
  • Myometrium (cytology, metabolism, pathology)
  • Polymerase Chain Reaction
  • Prognosis
  • Time Factors
  • Tumor Cells, Cultured
  • Uterine Neoplasms (metabolism, pathology, surgery)

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