Abstract | BACKGROUND: METHODS: We followed the clinical course of five pregnancies in two HFH patients, with attention to the effect of repeated plasma exchange on maternal and fetal status; specifically, lipid profile, hemodynamics, and uteroplacental circulation on Doppler flow study. RESULTS: CONCLUSIONS: Repeated pregnancies in HFH patients treated by long-term plasma exchange are feasible but may be associated with untoward effects, especially hemodynamic compromise. The frequency of plasma exchange therapy should be increased to prevent marked hypercholesterolemia and its possible deleterious effect on maternal and fetal status. Cardiac evaluation with close hemodynamic monitoring are needed during pregnancy to detect complications of the cardiac valvular lesion and the coronary atherosclerosis that are associated with HFH.
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Authors | Y Beigel, J Bar, M Cohen, M Hod |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 77
Issue 6
Pg. 603-8
(Jul 1998)
ISSN: 0001-6349 [Print] United States |
PMID | 9688236
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Cholesterol
(blood)
- Feasibility Studies
- Female
- Hemodynamics
- Homozygote
- Humans
- Hypercholesterolemia
(blood, diagnostic imaging, genetics, therapy)
- Plasma Exchange
- Pregnancy
- Pregnancy Complications, Hematologic
(blood, diagnostic imaging, therapy)
- Pregnancy Outcome
- Ultrasonography, Doppler
- Umbilical Cord
(blood supply, diagnostic imaging)
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