Abstract | BACKGROUND: Recent experimental studies support initial clinical impressions that laparoscopic surgery for malignant neoplasms may be associated with an increased incidence of metastases to port sites. This study investigated in an experimental model the influence of cytotoxic agents (administered intraperitoneally or intramuscularly) on the development of port-site metastases following laparoscopic surgery. METHODS: RESULTS: No tumor was found in any port site following the intraperitoneal administration of povidine- iodine (P=.04). In contrast, port-site metastases developed in the control group (5 [41.7%] of 12), the isotonic sodium chloride solution group (4 [33.3%] of 12), the chlorhexdine group (4 [33.3%] of 12), the intraperitoneal methotrexate group (2 [16.7%] of 12), and the parenteral methotrexate group (5 [41.7%] of 12). CONCLUSIONS: The results of this study suggest that the development of metastases to port sites following laparoscopic surgery may be prevented by the intraperitoneal instillation of diluted povodine- iodine. Other agents failed to influence the incidence of port-site metastases. Further studies are needed to determine if these findings can be applied to humans.
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Authors | S J Neuhaus, D I Watson, T Ellis, T Dodd, A M Rofe, G G Jamieson |
Journal | Archives of surgery (Chicago, Ill. : 1960)
(Arch Surg)
Vol. 133
Issue 7
Pg. 762-6
(Jul 1998)
ISSN: 0004-0010 [Print] United States |
PMID | 9688006
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Laparoscopy
(adverse effects)
- Male
- Neoplasm Seeding
- Postoperative Complications
(prevention & control)
- Rats
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