Abstract | BACKGROUND: METHODS: Two hundred ninety-nine pediatric patients (ages 1 month to 12 years) with pyelonephritis (300 episodes) were enrolled in a randomized, open label, multicenter trial. Individual results were evaluated by a blinded committee of experts. Cefepime was compared with ceftazidime, both administered parenterally at 50 mg/kg every 8 h. Patients were to receive the assigned study drug until at least 48 h after becoming afebrile. The i.v. treatment was then to be continued or replaced by oral trimethoprimsulfamethoxazole for a maximum of 12 to 14 days. RESULTS: The predominant causative pathogens were Escherichia coli, 88%; Proteus spp., 6%; Pseudomonas aeruginosa, 2%; and Klebsiella spp., 2%. Bacteriologic eradication was achieved in 96 and 94% of cefepime and ceftazidime patients, respectively, at the end of i.v. study drug treatment and was maintained in 94 and 91%, respectively, at the end of total study therapy. After study therapy bacteriologic eradication was maintained after 4 to 6 weeks in 86% of cefepime cases and in 83% of ceftazidime cases. A satisfactory clinical response occurred in 98 and 96% of cefepime and ceftazidime patients, respectively, at the end of i.v. treatment and in 93% at the end of total study therapy in both treatment arms. Drug-related clinical adverse events occurred in 14 cefepime patients (91%) and in 10 ceftazidime patients (7%). CONCLUSIONS:
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Authors | U B Schaad, J Eskola, D Kafetzis, M Fishbach, S Ashkenazi, V Syriopoulou, J Boulesteix, V De Pril, J J Grès, C Rollin |
Journal | The Pediatric infectious disease journal
(Pediatr Infect Dis J)
Vol. 17
Issue 7
Pg. 639-44
(Jul 1998)
ISSN: 0891-3668 [Print] United States |
PMID | 9686732
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cephalosporins
- Trimethoprim, Sulfamethoxazole Drug Combination
- Cefepime
- Ceftazidime
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Topics |
- Administration, Oral
- Cefepime
- Ceftazidime
(administration & dosage, therapeutic use)
- Cephalosporins
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Drug Therapy, Combination
(administration & dosage, therapeutic use)
- Female
- Humans
- Infant
- Injections, Intravenous
- Male
- Pyelonephritis
(drug therapy, microbiology)
- Trimethoprim, Sulfamethoxazole Drug Combination
(administration & dosage, therapeutic use)
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