Abstract |
Suprofen, an anti-inflammatory drug was incorporated in polymer networks based on biocompatible macromolecules, such as alpha,beta-polyasparthydrazide (PAHy) and alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide ( PHEA) crosslinked by glutaraldehyde or gamma-rays, respectively. Swelling tests carried out in aqueous media showed that pH value affects the swelling degree of the prepared hydrogels. In vitro release tests were performed in simulated gastrointestinal fluids (pH 1/6.8) using the pH variation method and in phosphate-buffered saline, pH 7.4. Experimental data indicated that Suprofen was released in a sustained way both from PAHy and PHEA microparticles. Further, incorporation of Suprofen in PAHy and PHEA networks provided a significant reduction of the drug photosensitizing activity, as evidenced by in vitro hemolysis tests.
|
Authors | G Giammona, G Pitarresi, V Tomarchio, G De Guidi, S Giuffrida |
Journal | Journal of controlled release : official journal of the Controlled Release Society
(J Control Release)
Vol. 51
Issue 2-3
Pg. 249-57
(Feb 12 1998)
ISSN: 0168-3659 [Print] Netherlands |
PMID | 9685923
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cross-Linking Reagents
- Delayed-Action Preparations
- Gels
- Hydrazines
- Nylons
- Peptides
- Photosensitizing Agents
- Plasma Substitutes
- alpha,beta-poly((2-hydroxyethyl)-aspartamide)
- alpha,beta-polyasparthydrazide
- Suprofen
- Glutaral
|
Topics |
- Anti-Inflammatory Agents, Non-Steroidal
(chemistry, pharmacology)
- Cross-Linking Reagents
(chemistry)
- Delayed-Action Preparations
- Erythrocytes
(drug effects)
- Gastric Juice
(metabolism)
- Gels
- Glutaral
(chemistry)
- Hemolysis
- Humans
- Hydrazines
(chemistry)
- Hydrogen-Ion Concentration
- Nylons
(chemistry)
- Particle Size
- Peptides
(chemistry)
- Photosensitizing Agents
(chemistry)
- Plasma Substitutes
- Suprofen
(chemistry, pharmacology)
|