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Swellable microparticles containing Suprofen: evaluation of in vitro release and photochemical behaviour.

Abstract
Suprofen, an anti-inflammatory drug was incorporated in polymer networks based on biocompatible macromolecules, such as alpha,beta-polyasparthydrazide (PAHy) and alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) crosslinked by glutaraldehyde or gamma-rays, respectively. Swelling tests carried out in aqueous media showed that pH value affects the swelling degree of the prepared hydrogels. In vitro release tests were performed in simulated gastrointestinal fluids (pH 1/6.8) using the pH variation method and in phosphate-buffered saline, pH 7.4. Experimental data indicated that Suprofen was released in a sustained way both from PAHy and PHEA microparticles. Further, incorporation of Suprofen in PAHy and PHEA networks provided a significant reduction of the drug photosensitizing activity, as evidenced by in vitro hemolysis tests.
AuthorsG Giammona, G Pitarresi, V Tomarchio, G De Guidi, S Giuffrida
JournalJournal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 51 Issue 2-3 Pg. 249-57 (Feb 12 1998) ISSN: 0168-3659 [Print] Netherlands
PMID9685923 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cross-Linking Reagents
  • Delayed-Action Preparations
  • Gels
  • Hydrazines
  • Nylons
  • Peptides
  • Photosensitizing Agents
  • Plasma Substitutes
  • alpha,beta-poly((2-hydroxyethyl)-aspartamide)
  • alpha,beta-polyasparthydrazide
  • Suprofen
  • Glutaral
Topics
  • Anti-Inflammatory Agents, Non-Steroidal (chemistry, pharmacology)
  • Cross-Linking Reagents (chemistry)
  • Delayed-Action Preparations
  • Erythrocytes (drug effects)
  • Gastric Juice (metabolism)
  • Gels
  • Glutaral (chemistry)
  • Hemolysis
  • Humans
  • Hydrazines (chemistry)
  • Hydrogen-Ion Concentration
  • Nylons (chemistry)
  • Particle Size
  • Peptides (chemistry)
  • Photosensitizing Agents (chemistry)
  • Plasma Substitutes
  • Suprofen (chemistry, pharmacology)

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