Abstract |
The El mouse is an established animal model for human epilepsy. We previously reported that the level of quinolinic acid (QUIN), an excitotoxin, was high in the brain of epilepsy-prone El mice and that the increased production of QUIN was secondary to an increased activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11. 6) in the brains of these mice. In this study, we cloned and sequenced the cDNA for 3-HAO and showed that its expression in the brain of El mice was higher than that of control ddY mice. These results suggest that a genetic defect leading to derepression of the 3-HAO gene expression in the brain may be involved in the pathogenesis for the epileptic diseases of El mice.
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Authors | Y Nakagawa, H Asai, T Miura, J Kitoh, H Mori, K Nakano |
Journal | Brain research. Molecular brain research
(Brain Res Mol Brain Res)
Vol. 58
Issue 1-2
Pg. 132-7
(Jul 15 1998)
ISSN: 0169-328X [Print] Netherlands |
PMID | 9685612
(Publication Type: Comparative Study, Journal Article)
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Copyright | Copyright 1998 Elsevier Science B.V. All rights reserved. |
Chemical References |
- DNA Primers
- DNA, Complementary
- Oligonucleotides, Antisense
- Peptide Fragments
- Recombinant Fusion Proteins
- Oxygenases
- Dioxygenases
- 3-Hydroxyanthranilate 3,4-Dioxygenase
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Topics |
- 3-Hydroxyanthranilate 3,4-Dioxygenase
- Amino Acid Sequence
- Animals
- Base Sequence
- Brain
(enzymology)
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Dioxygenases
- Disease Models, Animal
- Epilepsy
(enzymology, genetics)
- Gene Expression Regulation, Enzymologic
- Humans
- Mice
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Oligonucleotides, Antisense
- Open Reading Frames
- Oxygenases
(biosynthesis, chemistry, genetics)
- Peptide Fragments
(chemistry)
- Recombinant Fusion Proteins
(biosynthesis)
- Reference Values
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