The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor-alpha convertase.

Abstract

Angiotensin converting enzyme (ACE) and the Alzheimer's amyloid precursor protein are cleaved from the membrane by zinc metalloproteinases termed ACE secretase and alpha-secretase, respectively. Tumour necrosis factor-alpha (TNF-alpha) convertase (ADAM 17) is a recently identified member of the adamalysin family of mammalian zinc metalloproteinases that is involved in the production of TNF-alpha and possibly in the cleavage of other membrane proteins. Using two different cell-free assays we were unable to detect significant cleavage and secretion of ACE by TNF-alpha convertase. In addition, there was a different effect of three hydroxamic acid-based inhibitors (batimastat, compound 1 and compound 4) towards TNF-alpha convertase as compared to ACE secretase and alpha-secretase. Thus TNF-alpha convertase would appear to be distinct from, but possibly related to, the secretases that cleave ACE and the amyloid precursor protein.

• Authors: S Parvathy, E H Karran, A J Turner, N M Hooper
• Journal: FEBS letters (FEBS Lett) Vol. 431 Issue 1 Pg. 63-5 (Jul 10 1998) ISSN: 0014-5793 [Print] England
• PMID: 9684866 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amyloid beta-Protein Precursor
• Tumor Necrosis Factor-alpha
• Amyloid Precursor Protein Secretases
• Endopeptidases
• Peptidyl-Dipeptidase A
• ADAM Proteins
• Metalloendopeptidases
• ADAM17 Protein

Topics

• ADAM Proteins
• ADAM17 Protein
• Amyloid Precursor Protein Secretases
• Amyloid beta-Protein Precursor (metabolism)
• Animals
• Cell-Free System
• Endopeptidases (metabolism)
• Metalloendopeptidases (antagonists & inhibitors, metabolism)
• Peptidyl-Dipeptidase A (metabolism)
• Swine
• Tumor Necrosis Factor-alpha (metabolism)