Antithrombotic effects of YM-60828 in three thrombosis models in guinea pigs.

Abstract

The antithrombotic effects of a novel factor Xa inhibitor, YM-60828 ([N-[4-[(1-acetimidoyl-4-piperidyl)oxy]phenyl]-N-[(7-amidino-2-nap hthyl)methyl]sulfamoyl]acetic acid dihydrochloride), in three thrombosis models in guinea pigs were studied in comparison with its effect on bleeding time. The antithrombotic effects of YM-60828 were most pronounced in the venous thrombosis and the arterio-venous shunt models but YM-60828 showed 10-fold weaker effects in the carotid thrombosis model. However, YM-60828 prolonged bleeding time at a much higher dose than that required in all thrombosis models. In conclusion, YM-60828 exerted its antithrombotic effects without prolonging bleeding time in all thrombosis models and may be of clinical value not only in venous thrombosis but also in arterial thrombosis.

• Authors: K Sato, T Kawasaki, N Hisamichi, Y Taniuchi, F Hirayama, H Koshio, M Ichihara, Y Matsumoto
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 350 Issue 1 Pg. 87-91 (May 29 1998) ISSN: 0014-2999 [Print] Netherlands
• PMID: 9683019 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Factor Xa Inhibitors
• Fibrinolytic Agents
• Naphthalenes
• Piperidines
• YM 60828
• Antithrombin III

Topics

• Animals
• Antithrombin III (pharmacology, therapeutic use)
• Arteriovenous Shunt, Surgical
• Bleeding Time
• Carotid Artery Thrombosis (drug therapy, metabolism)
• Carotid Artery, Internal (drug effects)
• Disease Models, Animal
• Factor Xa Inhibitors
• Fibrinolytic Agents (therapeutic use)
• Guinea Pigs
• Male
• Naphthalenes (pharmacology, therapeutic use)
• Piperidines (pharmacology, therapeutic use)
• Thrombophlebitis (drug therapy, metabolism)
• Thrombosis (drug therapy)