Abstract | OBJECTIVE: METHODS: Nineteen patients, 11 (57.9%) with AHN and 8 (42.1 %) with PHN were given, on different days, a single 500-mg oral dose of ASA or a topical dose (750 mg) of (ADE) daubed onto the painful skin. The analgesic effect was assessed by means of a visual analogue scale (VAS). Overall pain relief was graded as: excellent, good, fair, or poor. AHN as well as PHN patients had severe pain at baseline (6.83 and 5.93). Levels of ASA and SA in plasma and in the stratum corneum after adhesive tape stripping of the treated area were determined by HPLC. RESULTS: After ADE application, the analgesic effect was very rapid and VAS scores were lower than at baseline. Pain significantly decreased by 82.6% after topical and 15.4% after oral ASA. After ADE, 95% of the patients had excellent or good pain relief, but after oral administration 79% of the patients had a poor response. Pain relief was similar in the two subgroups after ADE. Skin concentrations of ASA, but not of SA, after ADE were about 80- to 100-fold those after oral administration. Levels of ASA and SA in plasma after oral administration were similar to those previously found, but after ADE were undetectable or very low. Patients with excellent pain relief showed a trend towards higher ASA skin concentrations. CONCLUSIONS:
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Authors | S R Bareggi, R Pirola, G De Benedittis |
Journal | European journal of clinical pharmacology
(Eur J Clin Pharmacol)
Vol. 54
Issue 3
Pg. 231-5
(May 1998)
ISSN: 0031-6970 [Print] Germany |
PMID | 9681665
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Salicylates
- Solvents
- Ether
- Salicylic Acid
- Aspirin
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Topics |
- Acute Disease
- Administration, Oral
- Administration, Topical
- Aged
- Analgesics
(therapeutic use)
- Anti-Inflammatory Agents
(administration & dosage, blood, therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, blood, therapeutic use)
- Aspirin
(administration & dosage, blood, therapeutic use)
- Cross-Over Studies
- Double-Blind Method
- Ether
(administration & dosage, therapeutic use)
- Female
- Herpes Zoster
(complications, drug therapy)
- Herpesviridae Infections
(complications)
- Humans
- Male
- Middle Aged
- Neuralgia
(drug therapy, virology)
- Pain
(drug therapy)
- Pain Measurement
(drug effects)
- Salicylates
- Salicylic Acid
- Skin
(chemistry)
- Solvents
(administration & dosage, therapeutic use)
- Treatment Outcome
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