Bezafibrate has an antioxidant effect: peroxisome proliferator-activated receptor alpha is associated with Cu2+, Zn2+-superoxide dismutase in the liver.

Abstract	Administration of bezafibrate in rats significantly reduced the levels of plasma thiobarbituric acid-reactive substances (TBARS) in comparison with those obtained in rats fed a soy or lard chow. Moreover, an elevation of in vitro conjugated diene production and linoleic acid levels in the high-density lipoproteins and low-density lipoproteins induced by a soy or lard chow, was reduced by bezafibrate administration. In addition, the liver Cu2+, Zn2+-superoxide dismutase (SOD) gene expression showed a significant positive correlation with the liver peroxisome proliferator-activated receptor alpha (PPARalpha) mRNA level (R=0.769, p<0.0001). This unique characteristic of bezafibrate, which possesses both a hypolipidemic effect and antioxidant activity, may be beneficial in preventing vascular complications in hyperlipidemia.
Authors	I Inoue, S Noji, T Awata, K Takahashi, T Nakajima, M Sonoda, T Komoda, S Katayama
Journal	Life sciences (Life Sci) Vol. 63 Issue 2 Pg. 135-44 ( 1998) ISSN: 0024-3205 [Print] Netherlands
PMID	9674948 (Publication Type: Journal Article)
Chemical References	Antioxidants Dietary Fats Fatty Acids Hypolipidemic Agents Lipoproteins, HDL Lipoproteins, LDL Receptors, Cytoplasmic and Nuclear Thiobarbituric Acid Reactive Substances Transcription Factors Cholesterol Oxidoreductases Catalase Superoxide Dismutase Acyl-CoA Oxidase Bezafibrate
Topics	Acyl-CoA Oxidase Animals Antioxidants (pharmacology) Bezafibrate (pharmacology) Catalase (biosynthesis, metabolism) Cholesterol (blood) Diet Dietary Fats (administration & dosage) Fatty Acids (blood) Gene Expression Regulation, Enzymologic (drug effects) Hypolipidemic Agents (pharmacology) Lipoproteins, HDL (analysis, blood) Lipoproteins, LDL (analysis, blood) Liver (drug effects, enzymology, ultrastructure) Male Oxidoreductases (biosynthesis, metabolism) Rats Rats, Sprague-Dawley Receptors, Cytoplasmic and Nuclear (biosynthesis, physiology) Soybeans Superoxide Dismutase (biosynthesis) Thiobarbituric Acid Reactive Substances (metabolism) Transcription Factors (biosynthesis, physiology)

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