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Efficacy of difloxacin in growing broiler chickens for the control of infection due to pathogenic Mycoplasma gallisepticum.

Abstract
Chickens 14 days old were experimentally inoculated with Mycoplasma gallisepticum (MG) R-P10 strain. After development of respiratory symptoms, birds were left unmedicated or medicated for 5 consecutive days with Difloxacin 5, 7.5 or 10 mg/kg body weight per day or Enrofloxacin at the dose level of 10 mg/kg body weight per day. Evaluation of efficacy was based on body weight, symptoms, post-mortem findings, re-isolation of MG and serology. Results indicated that under the conditions of this experiment, treatment with 7.5 mg Difloxacin per kg body weight for 5 days was already effective against pathogenic MG infection. The dose of 10 mg/kg Difloxacin was equally effective as a dose of 10 mg/kg Enrofloxacin in treating respiratory symptoms.
AuthorsI Kempf, R van den Hoven, F Gesbert, M Guittet
JournalZentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B (Zentralbl Veterinarmed B) Vol. 45 Issue 5 Pg. 305-10 (Jun 1998) ISSN: 0514-7166 [Print] Germany
PMID9673582 (Publication Type: Journal Article)
Chemical References
  • Anti-Infective Agents
  • Fluoroquinolones
  • Quinolones
  • Enrofloxacin
  • Ciprofloxacin
  • difloxacin
Topics
  • Animals
  • Anti-Infective Agents (therapeutic use)
  • Chickens
  • Ciprofloxacin (analogs & derivatives, therapeutic use)
  • Enrofloxacin
  • Female
  • Fluoroquinolones
  • Male
  • Mycoplasma (isolation & purification)
  • Mycoplasma Infections (prevention & control, veterinary)
  • Poultry Diseases (prevention & control)
  • Quinolones (therapeutic use)

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