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Familial hemophagocytic lymphohistiocytosis: improved neurodevelopmental outcome after bone marrow transplantation.

Abstract
A child with familial hemophagocytic lymphohistiocytosis (HLH) underwent allogeneic bone marrow transplantation (BMT) at age 5 months. At that time he showed delayed psychomotor development, and computed tomography revealed diffuse calcification. After BMT, a gradual neurodevelopmental normalization was observed. The potential ability of BMT to reverse neurodevelopmental deterioration in HLH should be considered.
AuthorsA Shuper, D Attias, L Kornreich, R Zaizov, I Yaniv
JournalThe Journal of pediatrics (J Pediatr) Vol. 133 Issue 1 Pg. 126-8 (Jul 1998) ISSN: 0022-3476 [Print] United States
PMID9672524 (Publication Type: Case Reports, Journal Article)
Topics
  • Bone Marrow Transplantation
  • Brain (pathology)
  • Calcinosis (diagnosis)
  • Histiocytosis, Non-Langerhans-Cell (genetics, pathology, therapy)
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male

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