Incidence of exacerbations in the first 90 days of treatment with recombinant human interferon beta-1b in patients with relapsing-remitting multiple sclerosis.

Interferon beta-1b (IFNbeta-1b) is effective in reducing the frequency of exacerbations in patients with relapsing-remitting multiple sclerosis (RRMS). Recently, a study suggested that treatment with IFNbeta-1b may place MS patients at risk of exacerbations by increasing interferon-gamma (IFNgamma)-secreting cells in the blood early after onset of treatment. We conducted a retrospective study in 192 RRMS patients treated with IFNbeta-1b. We did not observe an increase in the frequency of exacerbations early after the onset of treatment and suggest that the IFNgamma-secreting cell surge linked to the onset of treatment with IFNbeta-1b may not be clinically significant.
AuthorsO A Khan, J R Hebel
JournalAnnals of neurology (Ann Neurol) Vol. 44 Issue 1 Pg. 138-9 (Jul 1998) ISSN: 0364-5134 [Print] UNITED STATES
PMID9667604 (Publication Type: Journal Article)
Chemical References
  • Glucocorticoids
  • Neuroprotective Agents
  • Recombinant Proteins
  • Interferon beta-1b
  • Interferon-beta
  • Prednisone
  • Methylprednisolone
  • Interferon beta-1a
  • Administration, Oral
  • Adult
  • Case-Control Studies
  • Female
  • Glucocorticoids (administration & dosage)
  • Humans
  • Incidence
  • Injections, Intravenous
  • Interferon beta-1a
  • Interferon beta-1b
  • Interferon-beta (adverse effects, therapeutic use)
  • Male
  • Methylprednisolone (administration & dosage)
  • Middle Aged
  • Multiple Sclerosis (therapy)
  • Nervous System Diseases (epidemiology, etiology, prevention & control)
  • Neuroprotective Agents (administration & dosage)
  • Prednisone (administration & dosage)
  • Recombinant Proteins (adverse effects, therapeutic use)
  • Recurrence
  • Retrospective Studies

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