HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Prognostic factors in muscle-invasive bladder cancer treated with radiotherapy: an immunohistochemical study.

AbstractOBJECTIVE:
To determine the prognostic role of p53, Ki-67 and p21 for patients with muscle-invasive bladder cancer treated with curative intent by radiotherapy.
PATIENTS AND METHODS:
The study included 131 patients (24 women and 107 men, median age 72 years, range 40-86) with transitional cell carcinoma (T2-T4) treated with external definitive pelvic radiotherapy between 1985 and 1994. Paraffin-embedded pretreatment biopsies from the patients were examined for the presence of p53, p21 and Ki-67, detected by immunohistochemistry, and related to tumour stage, grade and patient survival.
RESULTS:
The expression of p53 protein correlated positively with the detection of Ki-67 (P < 0.05) but did not correlate with p21. None of the immunohistochemical variables (p53, p21 or Ki-67) correlated with T category and only Ki-67 correlated with histological grade. Patients with > 5% p21 expression tended to live longer than those with < 5% (P = 0.09). In a multivariate analysis, the T category (T2/T3 vs. T4), histological grade (2 vs. 3) and p21 expression (< or = 5% vs. > 5%) were independent prognostic factors for overall survival.
CONCLUSION:
Further investigation is warranted in patients with muscle-invasive bladder cancer undergoing different types of treatment p21 seems to play an independent prognostic role in these patients, in addition to T category and grade.
AuthorsI Osen, S D Fosså, B Majak, R Røtterud, A Berner
JournalBritish journal of urology (Br J Urol) Vol. 81 Issue 6 Pg. 862-9 (Jun 1998) ISSN: 0007-1331 [Print] England
PMID9666772 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Enzyme Inhibitors
  • Ki-67 Antigen
  • Neoplasm Proteins
  • Tumor Suppressor Protein p53
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Carcinoma, Transitional Cell (metabolism, radiotherapy)
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins (metabolism)
  • Enzyme Inhibitors (metabolism)
  • Female
  • Humans
  • Immunohistochemistry (methods)
  • Ki-67 Antigen (metabolism)
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Proteins (metabolism)
  • Prognosis
  • Survival Analysis
  • Tumor Suppressor Protein p53 (metabolism)
  • Urinary Bladder Neoplasms (metabolism, radiotherapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: