Abstract | OBJECTIVE: To determine the prognostic role of p53, Ki-67 and p21 for patients with muscle-invasive bladder cancer treated with curative intent by radiotherapy. PATIENTS AND METHODS: The study included 131 patients (24 women and 107 men, median age 72 years, range 40-86) with transitional cell carcinoma (T2-T4) treated with external definitive pelvic radiotherapy between 1985 and 1994. Paraffin-embedded pretreatment biopsies from the patients were examined for the presence of p53, p21 and Ki-67, detected by immunohistochemistry, and related to tumour stage, grade and patient survival. RESULTS: The expression of p53 protein correlated positively with the detection of Ki-67 (P < 0.05) but did not correlate with p21. None of the immunohistochemical variables (p53, p21 or Ki-67) correlated with T category and only Ki-67 correlated with histological grade. Patients with > 5% p21 expression tended to live longer than those with < 5% (P = 0.09). In a multivariate analysis, the T category (T2/T3 vs. T4), histological grade (2 vs. 3) and p21 expression (< or = 5% vs. > 5%) were independent prognostic factors for overall survival. CONCLUSION: Further investigation is warranted in patients with muscle-invasive bladder cancer undergoing different types of treatment p21 seems to play an independent prognostic role in these patients, in addition to T category and grade.
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Authors | I Osen, S D Fosså, B Majak, R Røtterud, A Berner |
Journal | British journal of urology
(Br J Urol)
Vol. 81
Issue 6
Pg. 862-9
(Jun 1998)
ISSN: 0007-1331 [Print] England |
PMID | 9666772
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- CDKN1A protein, human
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme Inhibitors
- Ki-67 Antigen
- Neoplasm Proteins
- Tumor Suppressor Protein p53
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Carcinoma, Transitional Cell
(metabolism, radiotherapy)
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
(metabolism)
- Enzyme Inhibitors
(metabolism)
- Female
- Humans
- Immunohistochemistry
(methods)
- Ki-67 Antigen
(metabolism)
- Male
- Middle Aged
- Multivariate Analysis
- Neoplasm Proteins
(metabolism)
- Prognosis
- Survival Analysis
- Tumor Suppressor Protein p53
(metabolism)
- Urinary Bladder Neoplasms
(metabolism, radiotherapy)
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