[Intravenous immunoglobulin (GB-0998) for prophylaxis of recurrent acute otitis media and lower respiratory tract infection in infancy with IgG 2 deficiency].

Abstract

The prophylactic effect of intravenous immunoglobulin (GB-0998) on the recurrent acute otitis media, bronchitis and bronchopneumonia in IgG 2 deficient infants was investigated in a multicenter trial. GB-0998 was administered 6 times every 4 weeks. The doses were 300 mg/kg wt. during the first treatment, followed by 5 doses of 200 mg/kg wt. The results indicated that GB-0998 was effective in the prophylaxis of the recurrent infection of acute otitis media, bronchitis and bronchopneumonia in infancy with IgG 2 deficiency and/or IgG 2 antibody deficiency specific for Streptococcus pneumoniae.

• Authors: Y Sakiyama, A Komiyama, K Shiraki, N Taniguchi, S Torii, S Baba, J Yata, S Matsumoto
• Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology (Nihon Rinsho Meneki Gakkai Kaishi) Vol. 21 Issue 2 Pg. 70-9 (Apr 1998) ISSN: 0911-4300 [Print] Japan
• PMID: 9666680 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)

Chemical References

• Immunoglobulins, Intravenous

Topics

• Acute Disease
• Bronchitis (prevention & control)
• Child, Preschool
• Female
• Humans
• IgG Deficiency (therapy)
• Immunoglobulins, Intravenous (therapeutic use)
• Infant
• Male
• Otitis Media (prevention & control)
• Pneumonia (prevention & control)
• Recurrence