Abstract | BACKGROUND: METHODS: Fifty patients with active ulcerative colitis extending not beyond 20 cm from the anus on sigmoidoscopy, participated in a randomized single-blind study comparing the efficacy, tolerance and acceptance of the new Pentasa mesalazine 1 g suppository, given once daily versus Claversal mesalazine 500 mg suppository b.d. RESULTS: After 2 weeks, clinical remission was observed in 16 of 25 (64%) in the Pentasa group and in 7 of 25 (28%) in the Claversal 500 mg b.d. treated group; sigmoidoscopic remission occurred in 13 of 25 (52%) in the Pentasa group and in six of 25 (24%) in the Claversal group (P < 0.01). After 4 weeks, clinical and sigmoidoscopic remission were observed, respectively, in 84 and 76% of patients treated with Pentasa suppositories, and in 80 and 72% of patients treated with Claversal suppositories 500 mg b.d. (P = N.S.). The patients' evaluation for tolerability and practicality showed that the Pentasa suppository was significantly superior to the Claversal suppository. CONCLUSIONS:
Pentasa 1 g suppository once daily induces a quicker clinical and sigmoidoscopic remission, and was better tolerated, than the Claversal 500 mg suppository b.d., and it may represent an advance for the topical treatment of distal proctosigmoiditis.
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Authors | P Gionchetti, F Rizzello, A Venturi, C Brignola, M Ferretti, S Peruzzo, M Campieri |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 11
Issue 6
Pg. 1053-7
(Dec 1997)
ISSN: 0269-2813 [Print] England |
PMID | 9663829
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Suppositories
- Mesalamine
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Topics |
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects)
- Drug Administration Schedule
- Female
- Humans
- Male
- Mesalamine
(administration & dosage, adverse effects)
- Middle Aged
- Patient Satisfaction
- Proctitis
(drug therapy)
- Proctocolitis
(drug therapy)
- Single-Blind Method
- Suppositories
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