Abstract | BACKGROUND: Surgical excision of liver tumors represents the only curative treatment for primary and metastatic liver malignancies. It has been suspected that hepatectomy may stimulate growth of microscopic tumors. To determine whether local or systemic factors after hepatectomy are responsible for enhancement of tumor growth, the effects of hepatectomy on the experimental growth of liver or pulmonary tumors were examined. METHODS: One hour after injection of 10(6) Morris hepatoma cells into either the portal or femoral vein, which produces isolated liver and lung tumors, respectively, animals were randomized to undergo 0%, 30%, or 70% partial hepatectomy (PH). RESULTS: CONCLUSIONS:
|
Authors | A Picardo, H M Karpoff, B Ng, J Lee, M F Brennan, Y Fong |
Journal | Surgery
(Surgery)
Vol. 124
Issue 1
Pg. 57-64
(Jul 1998)
ISSN: 0039-6060 [Print] United States |
PMID | 9663252
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Transforming Growth Factor alpha
- Transforming Growth Factor beta
- Fibroblast Growth Factor 2
|
Topics |
- Animals
- Carcinoma, Hepatocellular
(metabolism, pathology)
- Fibroblast Growth Factor 2
(blood, metabolism)
- Hepatectomy
(methods)
- Injections, Intravenous
- Liver
(metabolism)
- Liver Neoplasms, Experimental
(metabolism, pathology)
- Lung Neoplasms
(pathology)
- Male
- Neoplasm Transplantation
- Neoplasms, Experimental
(pathology)
- Rats
- Rats, Inbred BUF
- Transforming Growth Factor alpha
(blood, metabolism)
- Transforming Growth Factor beta
(blood, metabolism)
|