HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

A study of chromosomes of schistosomiasis patients under oxaminiquine (UK 4271) treatment.

Abstract
Blood samples from 24 patients infested with Schistosoma mansoni were drawn immediately before and 2 days after the administration of a single therapeutic dose of 12-15 mg/kg oral oxaminiquine. Two-day lymphocyte cultures were obtained and about 100 mitoses from each blood sample were analyzed for chromosome aberrations. No significant differences were observed between the "before" and "after" cultures in the frequencies of aberrations resulting from spindle, chromatidic, or chromosome events. It is concluded that there is no reason to fear harmful effects on the chromosomes of patients from treatment with oxaminiquine.
AuthorsM V Monsalve, O Frota-Pessoa, A M Campos, H Sette
JournalJournal of toxicology and environmental health (J Toxicol Environ Health) Vol. 1 Issue 6 Pg. 1023-6 (Jul 1976) ISSN: 0098-4108 [Print] United States
PMID966313 (Publication Type: Journal Article)
Chemical References
  • Nitroquinolines
  • Oxamniquine
Topics
  • Chromatids (drug effects)
  • Chromosomes (drug effects)
  • Humans
  • Lymphocytes (ultrastructure)
  • Nitroquinolines (adverse effects)
  • Oxamniquine (adverse effects, therapeutic use)
  • Schistosoma mansoni
  • Schistosomiasis (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: