Abstract | OBJECTIVE: SUMMARY:
PDT is currently being investigated as an adjuvant treatment to surgical resection and/or radio chemotherapy of intracranial neoplasms. While possible neurotoxic side effects of the treatment have been noted, only limited preclinical data quantifying the response of intracranial normal and tumor tissues following PDT are available. MATERIALS AND METHODS: RESULTS: For Photofrin, AlClPc, and SnET2 (in an emulsion delivery vehicle) normal grey and white matter were very sensitive to PDT, showing a significantly lower threshold dose value than VX2-tumor. For ALA-induced PpIX and SnET2 (in liposome) very little or no white matter damage was observed. Additionally, ALA- PpIX showed significantly lower concentration in white matter than in cortex and tumor. Normal brain structures lacking a blood-brain barrier showed high uptake of all photosensitizers and, hence, are at risk of collateral damage during PDT. CONCLUSIONS: For clinical PDT of most adult intracranial neoplasms ALA-induced PpIX appears to be promising, and SnET2 (liposomal) has potential for selective tumor destruction with relative sparing of white matter. Other normal brain structures and, for the other photosensitizers, also white matter are at risk of collateral damage, if exposed to light during PDT.
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Authors | L Lilge, B C Wilson |
Journal | Journal of clinical laser medicine & surgery
(J Clin Laser Med Surg)
Vol. 16
Issue 2
Pg. 81-91
(Apr 1998)
ISSN: 1044-5471 [Print] United States |
PMID | 9663099
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Indoles
- Organometallic Compounds
- Photosensitizing Agents
- Porphyrins
- Protoporphyrins
- chloroaluminum phthalocyanine
- tin etiopurpurin
- Argon
- Dihematoporphyrin Ether
- protoporphyrin IX
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Topics |
- Animals
- Argon
- Brain
(drug effects, metabolism)
- Brain Neoplasms
(drug therapy, metabolism)
- Dihematoporphyrin Ether
(administration & dosage, pharmacokinetics, therapeutic use)
- Dose-Response Relationship, Drug
- Evaluation Studies as Topic
- Hematoporphyrin Photoradiation
- Indoles
(administration & dosage, pharmacokinetics, therapeutic use)
- Laser Therapy
- Male
- Organometallic Compounds
(administration & dosage, pharmacokinetics, therapeutic use)
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, pharmacokinetics, therapeutic use)
- Porphyrins
(administration & dosage, pharmacokinetics, therapeutic use)
- Protoporphyrins
(administration & dosage, pharmacokinetics, therapeutic use)
- Rabbits
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