Comparative study of tolerability and efficacy of iron protein succinylate versus iron hydroxide polymaltose complex in the treatment of iron deficiency in children.

Abstract	One-hundred children, 48 males and 52 females, mean age +/- SD 39.9 +/- 28.2 months (range 12 to 113) with sideropenia or sideropenic anemia were randomly divided into 2 groups of 50 patients each (groups A and B) and were treated with iron protein succinylate (group A) or iron hydroxide polymaltose complex (group B). Patients of both groups received 4 mg/kg elemental iron, maximally 80 mg daily, for 2 months. Side-effects of therapy and laboratory values (RBC, hematocrit, hemoglobin, MCV, serum iron, total iron binding capacity, and ferritin) were registered before treatment, 30 days after the beginning of therapy as well as after 60 days in order to evaluate tolerability and efficacy of the drugs. Both drugs were well tolerated and showed only few adverse reactions, which were comparable in severity and frequency. Iron protein succinylate led not only to a faster increase of hemoglobin, hematocrit, MCV, serum iron, and ferritin than iron hydroxide polymaltose complex, but the laboratory values remained higher in group A than in B even after 2 months of treatment.
Authors	F A Haliotis, D A Papanastasiou
Journal	International journal of clinical pharmacology and therapeutics (Int J Clin Pharmacol Ther) Vol. 36 Issue 6 Pg. 320-5 (Jun 1998) ISSN: 0946-1965 [Print] Germany
PMID	9660039 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References	Ferric Compounds Hematinics Hemoglobins Metalloproteins Succinates teferrol iron protein succinylate
Topics	Abdominal Pain (chemically induced) Anemia, Iron-Deficiency (drug therapy) Child Child, Preschool Diarrhea (chemically induced) Drug Tolerance Erythrocyte Indices (drug effects) Erythrocytes (chemistry, drug effects, metabolism) Female Ferric Compounds (adverse effects, therapeutic use) Hematinics (adverse effects, therapeutic use) Hematocrit Hemoglobins (drug effects) Humans Infant Male Metalloproteins (adverse effects, therapeutic use) Nausea (chemically induced) Succinates (adverse effects, therapeutic use) Treatment Outcome Vomiting (chemically induced)

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