Abstract | OBJECTIVE: METHODS: RESULTS: The plasma levels of IFNalpha and IFNgamma were significantly elevated from 4.7 U/ml to 12.6 U/ml and 0.3 U/ml to 3.4 U/ml, respectively, whereas the antipyrine clearance showed a decrease from 57.9 ml/min to 45 ml/min in the symptomatic interval of an acute viral infection. During therapy with low-dose interferons we observed a significant difference after 12 week treatment with IFNalpha or IFNbeta, respectively. In the first group we observed a decreased antipyrine clearance from 49.0 ml/min to 41.7 ml/min; in the second group the antipyrine clearance decreased from 49.0 ml/min to 41.7 ml/min. CONCLUSION:
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Authors | N H Brockmeyer, B Barthel, L Mertins, M Goos |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 36
Issue 6
Pg. 309-11
(Jun 1998)
ISSN: 0946-1965 [Print] Germany |
PMID | 9660037
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Antiviral Agents
- Interferon-alpha
- Interferon-beta
- Interferon-gamma
- Antipyrine
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Topics |
- Adult
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacokinetics)
- Antipyrine
(pharmacokinetics)
- Antiviral Agents
(administration & dosage, therapeutic use)
- Biotransformation
- Female
- HIV Infections
(drug therapy)
- Humans
- Influenza, Human
(physiopathology)
- Interferon-alpha
(administration & dosage, blood, therapeutic use)
- Interferon-beta
(administration & dosage, blood, therapeutic use)
- Interferon-gamma
(blood, drug effects)
- Male
- Metabolic Clearance Rate
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