Abstract | OBJECTIVE: To investigate the potential allergenic role of the yeast Malassezia pachydermatis in dogs with clinical diagnosis of atopic dermatitis. ANIMALS: 5 clinically normal nonatopic dogs, 10 atopic dogs with cytologic evidence of Malassezia dermatitis, and 12 atopic dogs without cytologic evidence of Malassezia dermatitis. PROCEDURE: A crude yeast extract was produced by disrupting the cell wall of M pachydermatis. The crude extract and 8 of its fractions, which were generated by fractionation in a high-performance liquid chromatography column, were injected along with 46 commercial allergens for intradermal allergy testing of normal and atopic sample populations. Significant difference between atopic populations was evaluated, using a threshold concentration of crude yeast extract that failed to induce wheal-and-flare responses in normal nonatopic dogs. RESULTS: CONCLUSIONS: CLINICAL RELEVANCE: Currently, Malassezia dermatitis is principally managed by use of antifungal chemotherapy. Because the yeast appears to be a contributing allergen in dogs with atopic dermatitis, hyposensitization with M pachydermatis extracts may offer a future alternative to extended or repeated episodic administration of antifungals for extended control of recurrent infections.
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Authors | D O Morris, N B Olivier, E J Rosser |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 59
Issue 7
Pg. 836-41
(Jul 1998)
ISSN: 0002-9645 [Print] United States |
PMID | 9659547
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Allergens
- Antigens, Fungal
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Topics |
- Allergens
- Animals
- Antigens, Fungal
(immunology)
- Dermatitis, Atopic
(immunology, veterinary)
- Dog Diseases
(immunology)
- Dogs
- Hypersensitivity
- Malassezia
(immunology)
- Skin Tests
(veterinary)
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